Table 1. The central composite design for optimization of ultrasound extraction conditions of peony root

Xn Response variables Levels
−2 −1 0 1 2
X1 Ethanol concentration (%) 20 40 60 80 100
X2 Extraction temperature (°C) 30 40 50 60 70
X3 Extraction time (min) 15 25 35 45 55